The cumulative effect builds over 2 to 4 weeks of consistent injections, which is why Triny typically recommends a loading phase before transitioning to monthly maintenance
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[25,59, 60, 61] Tolerization with hCDR1 induced both CD4 + CD25 + and CD8 + CD28 T regs in mice, which suppressed lymphocyte proliferation and autoantibody production
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